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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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Minerva Endocrinologica 2017 Nov 10

DOI: 10.23736/S0391-1977.17.02660-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer

Yao-Fang LIU , Fang WANG, Gui-Ying HUANG, Xi-Guang MAO

Department of Reproductive Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China


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OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation.
METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was analyzed.
RESULTS: During the 426 cycles, clinical pregnancy rate was 49.77% and embryo implantation rate was 27.20%. Differences in estradiol and progesterone levels on the day of endometrial transformation and before transplantation between pregnant and non-pregnant groups were not statistically significant. Furthermore, embryo implantation rate and clinical pregnancy rate among different levels of estradiol patients was not statistical different. On the day before transplantation, serum estradiol level decreased in 98.36% of patients. Differences in implantation rate and clinical pregnancy rate among patients with different extents of decrease in estradiol and different progesterone levels on the day before transplantation were statistically significant (P<0.05).
CONCLUSION: The extent of decrease in serum estradiol and progesterone levels on the day before transplantation may be associated with outcome of HRT-FET.


KEY WORDS: Frozen thawed embryo transfer - Replacement cycle - Hormone - Pregnancy

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Publication History

Article first published online: November 10, 2017
Manuscript accepted: November 8, 2017
Manuscript revised: August 30, 2017
Manuscript received: April 24, 2017

Cite this article as

Liu YF, Wang F, Huang GY, Mao XG. The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer. Minerva Endocrinol 2017 Nov 10. DOI: 10.23736/S0391-1977.17.02660-8

Corresponding author e-mail

happyyaofangliu@163.com