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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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Minerva Endocrinologica 2017 Sep 25

DOI: 10.23736/S0391-1977.17.02745-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Diagnosis and management of Zollinger-Ellison syndrome in 2017

Claudio DE ANGELIS , Pablo CORTEGOSO VALDIVIA, Ludovica VENEZIA, Mauro BRUNO, Rinaldo PELLICANO

Department of Gastroenterology and Digestive Endoscopy, “AOU Città della Salute e della Scienza”, University of Turin, Turin, Italy


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Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are considered typical, the diagnosis of ZES is often challenging for the clinician. A previous review was published in 2005 by our group, but in 12 years many things have changed: the diagnostic tools have been improved and many different therapeutical options are now available.


KEY WORDS: Neuroendocrine tumors - Gastrinoma - Zollinger-Ellison syndrome

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Publication History

Article first published online: September 25, 2017
Manuscript accepted: September 20, 2017
Manuscript received: September 14, 2017

Cite this article as

De Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R. Diagnosis and management of Zollinger-Ellison syndrome in 2017. Minerva Endocrinol 2017 Sep 25. DOI: 10.23736/S0391-1977.17.02745-6

Corresponding author e-mail

eusdeang@hotmail.com