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Minerva Endocrinologica 2019 December;44(4):387-96

DOI: 10.23736/S0391-1977.18.02867-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Bone health among patients with primary aldosteronism: a systematic review and meta-analysis

Huai H. LOH 1 , Anne YEE 2, Huai S. LOH 3

1 Faculty of Medicine and Health Sciences, University of Malaysia, Sarawak, Malaysia; 2 Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 3 Clinical Academic Unit, Newcastle University Medicine Malaysia, Johor, Malaysia



INTRODUCTION: Recent studies showed a possible association between hyperaldosteronism and secondary hyperparathyroidism leading to reduced bone health, however results are conflicting.
EVIDENCE ACQUISITION: We conducted a meta-analysis to evaluate the relationship between primary aldosteronism (PA) with bone biochemical markers and to assess bone mineral density in patients with primary aldosteronism.
EVIDENCE SYNTHESIS: A total of 939 subjects were examined (37.5% with PA). Patients with PA had significantly higher serum parathyroid hormone, lower serum calcium, higher urine calcium excretion and higher serum alkaline phosphatase compared to patients without PA, with no significant difference in serum vitamin D between both groups. Bone mineral density of lumbar spine, femoral neck and total neck of femur were similar between two groups. With PA treatment, there was a significant increment in serum calcium and reduction in serum parathyroid hormone.
CONCLUSIONS: PA is associated with hypercalciuria with subsequent secondary hyperparathyroidism. This potentially affects bone health. We recommend this to be part of complication screening among patients with PA.


KEY WORDS: Bone density; Calcium; Bone fractures; Hyperaldosteronism; Osteoporosis; Secondary hyperparathyroidism

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