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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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REVIEW  THE EVOLUTION OF IVF


Minerva Endocrinologica 2018 March;43(1):50-6

DOI: 10.23736/S0391-1977.17.02638-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Ovarian hyperstimulation syndrome management strategies: where are we going?

Ashley M. ESKEW, Kenan R. OMURTAG

Department of Reproductive Endocrinology and Infertility, Washington University School of Medicine, St. Louis, MO, USA


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Ovarian hyperstimulation syndrome (OHSS) is one of the most frequent, serious and potentially lethal iatrogenic complications of controlled ovarian stimulation. Despite extensive research, the exact pathogenesis of this syndrome remains less clear, but there appears to be a relationship of increased vascular permeability mediated by HCG and other downstream mediators. Adequate experience with ovulation induction therapy and identifying patients with known risk factors are essential in preventing OHSS. As this is a completely iatrogenic disease numerous strategies have been investigated to help decrease the risk of OHSS and their effects on pregnancy and live birth rate. What follows is a review of the common strategies apply today to minimize risk of OHSS in patients undergoing assisted reproductive technologies.


KEY WORDS: Ovarian hyperstimulation syndrome - Gonadotropins - Leuprolide

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Publication History

Issue published online: January 11, 2018
Article first published online: March 21, 2107

Cite this article as

Eskew AM, Omurtag KR. Ovarian hyperstimulation syndrome management strategies: where are we going? Minerva Endocrinol 2018;43:50-6. DOI: 10.23736/S0391-1977.17.02638-4

Corresponding author e-mail

omurtagk@wudosis.wustl.edu