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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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REVIEW  ENDOCRINE AND METABOLIC DISORDERS INTERPLAYING WITH NON-ALCOHOLIC FATTY LIVER DISEASEFREEfree


Minerva Endocrinologica 2017 June;42(2):132-44

DOI: 10.23736/S0391-1977.16.02500-1

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Novel perspectives on hypothalamic-pituitary dysfunction as a risk factor for non-alcoholic fatty liver disease

Anika HOFFMANN, Hermann L. MÜLLER

Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Oldenburg, Germany


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Non-alcoholic fatty liver disease (NAFLD) presents a disease with a wide spectrum spanning from benign steatosis to steatohepatitis with fibrosis and scarring that can lead to cirrhosis. With increasing prevalence, NAFLD is developing into the leading indication for liver transplantation worldwide. Disturbances in endocrine, hypothalamic-pituitary axes have been associated with NALFD, including GH deficiency, hypothyroidism, hypercortisolemia, and hypogonadism. In this review, we examine the published data (search: PUBMED, 1990-2016) suggesting a link between endocrine abnormalities of hypothalmic-pituitary axes and NAFLD and summarize the clinical data on risk factors for NAFLD in specific diseases involving hypothalmic-pituitary axes. Hormonal substitution of endocrine deficiencies has been shown to have beneficial effects at least in some instances. While the association between type 2 diabetes and NAFLD is well known, there is rather limited appreciation of the condition among common endocrine diseases involving hypothalamic-pituitary axes. In diseases involving hypothalamic-pituitary areas and manifesting clinically with endocrine deficiencies of hypothalamic-pituitary axes such as childhood-onset craniopharyngioma NAFLD is a frequent sequela of hypothalmic obesity.


KEY WORDS: Craniopharyngioma – Hypothalamus – Pituitary – Obesity - Non-alcoholic fatty liver disease - Liver cirrhosis

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Publication History

Issue published online: February 6, 2017
Article first published online: July 13, 2016

Cite this article as

Hoffmann A, Müller HL. Novel perspectives on hypothalamic-pituitary dysfunction as a risk factor for non-alcoholic fatty liver disease. Minerva Endocrinol 2017;42:132-44. DOI: 10.23736/S0391-1977.16.02500-1

Corresponding author e-mail

mueller.hermann@klinikum-oldenburg.de