Home > Journals > Minerva Endocrinologica > Past Issues > Minerva Endocrinologica 2017 June;42(2) > Minerva Endocrinologica 2017 June;42(2):92-108

CURRENT ISSUE
 

ARTICLE TOOLS

Publication history
Reprints
Cite this article as

MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,383


eTOC

 

REVIEW  ENDOCRINE AND METABOLIC DISORDERS INTERPLAYING WITH NON-ALCOHOLIC FATTY LIVER DISEASEFREEfree


Minerva Endocrinologica 2017 June;42(2):92-108

DOI: 10.23736/S0391-1977.16.02563-3

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Adipose tissue, obesity and non-alcoholic fatty liver disease

Stergios A. POLYZOS 1, Jannis KOUNTOURAS 1, Christos S. MANTZOROS 2, 3

1 Department of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece; 2 Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 3 Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA


PDF  


The association of obesity with non-alcoholic fatty liver disease (NAFLD) has been established. Obesity has been linked not only to initial stages of the disease, i.e., simple steatosis (SS), but also to its severity. From an epidemiologic point of view, both diseases has an increasing prevalence worldwide. From a pathogenetic point of view, obesity and its associate IR contribute to the initial fat accumulation in the hepatocyte (SS), but also to the progression of SS to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular carcinoma (HCC). From a clinical point of view, obesity has increased morbidity and mortality when combined with NAFLD, owing to cardiovascular and liver-specific mortality, including higher HCC risk. From a therapeutic point of view, weight loss is regarded as the cornerstone for the disease prevention and treatment. Although diet and exercise are the first choice to this aim, they are both difficult to achieve and sustain. Thus, the need for pharmacological treatment is considered of high importance. To treat obesity through pharmacologic weight loss, orlistat has been investigated, though with limited efficacy. Currently, liraglutide appears to be more efficacious, but it has not been officially approved for specifically NASH patients. Bariatric surgery is another alternative for severely obese patients showing histological improvement in NASH patients. However, since relative data from randomized trials are very limited, morbid obesity-related NASH patients may be subjected to bariatric surgery only after a careful individualized risk-benefit assessment.


KEY WORDS: Adipokines - Adiponectin - Leptin - Non-alcoholic fatty liver disease - Non-alcoholic steatohepatitis

top of page

Publication History

Issue published online: February 6, 2017
Article first published online: October 6, 2016

Cite this article as

Polyzos SA, Kountouras J, Mantzoros CS. Adipose tissue, obesity and nonalcoholic fatty liver disease. Minerva Endocrinol 2017;42:92-108. DOI: 10.23736/S0391-1977.16.02563-3

Corresponding author e-mail

stergios@endo.gr