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  GROWTH HORMONE: PHYSIOPATHOLOGY 

Minerva Endocrinologica 2002 December;27(4):277-86

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

Growth hormone-releasing hormone and pituitary somatotrope proliferation

Frohman L. A., Kineman R. D.


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Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH secretion and/or action result in dysregulated somatotrope proliferation, leading to hyperplasia and neoplastic transformation. Our understanding of the molecular and morphologic bases for these effects from both animal and clinical studies has greatly increased during the past decade. However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis.

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