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Minerva Stomatologica 2003 June;52(6):273-8

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: Italian

Systemic administration of capsaicin for the treatment of the Burning Mouth Syndrome

Lauritano D., Petruzzi M., Baldoni M.


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Aim. Burning mouth syndrome could be considered an expression of atypical facial pain. The recent neuropathological findings in BMS may suggest the need for alternative the-rapies. This paper aims to evaluate if syste-mic capsaicin could be used for BMS the- rapy.
Methods. Eighty-four BMS patients (19 males and 63 females, aged 36 to 74 years, mean 54.6) were referred to the Oral Medicine and Oral Pathology Department, Dental University Institute, Milan-Bicocca University. They were divided in 2 groups: 1st Group: the first group (42 patients) received 3 capsules of capsaicin (50 mg of powder of red pepper with 0,25% of capsaicin) a day for one month. 2nd Group: the control group (42 patients) received 3 capsules of placebo (empty capsules) a day for one month. The intensity of pain was measured on the visuo-analogical scale VAS. T test of Student was applied to analyse results of VAS. P values of less than 0.05 were interpreted as significant, and the level in confidence intervals was 95%.
Results. Significant differences were noted between the two groups at the end of our study (p<0.05). No important side effects were reported.
Conclusion. Systemic capsaicin could be considered a successful therapeutical approach for BMS patients.

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