ORIGINAL ARTICLES   

Minerva Stomatologica 1999 May;48(5):191-202

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: English, Italian

Microbiotica associated with refractory periodontis. Prevalence and antibiotic susceptibility

Barone A., Sbordone L., Ramaglia L., Ciaglia R. N.

Background. The aim of the present study was to analyze the composition of subgingival microflora in patients with refractory periodontitis and to evaluate the antimicrobial sensitivity of isolated periodontopathic microrganims to different antibiotics.
Methods. Eleven subjects with a mean age of 46.4 years were selected for the present study. All had been treated for periodontal disease in the past. After further disease progression patients were included in this study. Eight subgingival plaque samples per patients were collected for cultural analysis.
Results. ''Black pigmenting anaerobic bacilli'' were the pathogenic microrganisms more frequently isolated. The findings from antibiotic susceptibility test showed that high number of bacteria associated with refractory periodontitis resulted resistent to eritromycin, metronidazole and tetraycline. The most effective antibiotics were ciprofloxacin, amoxicillin-metronidazole and amoxicillin-clavulanic acid.
Conclusions. Microbiological analysis and antibiotic susceptibility test should be considered important tools in the management of patients with poor clinical response to conventional periodontal treatment.