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MINERVA CHIRURGICA

A Journal on Surgery


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Minerva Chirurgica 2017 May 30

DOI: 10.23736/S0026-4733.17.07382-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Influence of nodal status on the surgical outcome for bronchongenic carcinoma involving the carina: a systematic review and meta-analysis

Hai LIN, Yadong LU, Tao GU, Jun WANG

Department of Cardiothoracic Surgery, Zhangjiagang First People’s Hospital, Zhangjiagang, Jiangsu, China


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BACKGROUND: Bronchogenic carcinomas involving the carina or the tracheo-bronchial angle represents a challenging surgical procedure because of difficult surgical techniques and complex ventilation procedures. Eventhough surgical outcomes for this type of procedure has improved over time, the need for surgical management of patients with metastatic mediastinal nodes, that is those that are graded N2 or higher according to the TNM classification, is still controversial.
METHODS: We searched Pubmed, Embase and CNKI for literature in English or Chinese reporting on this subject, with information on survival rates or survival curves for groups with different grades of nodal status. We then performed a meta-analysis by grouping N0 and N1 patients and compared the surgical outcomes to those graded as N2 or higher. Hazard Ratios for each study were derived from the Kaplan-Meier survival curve.
RESULTS: Seven studies were included in this meta-analysis. The calculated hazard ratios ranged from 0.146 to 0.455. The weighted average hazard ratio for the N0/N1 group as compared to the N2/N3 group was 0.261 (Confidence interval: 0.154 - 0.441). The Galbraith plot confirmed the homogeneity of the studies included.
CONCLUSIONS: Carinal resection and reconstruction remains a challenging surgical procedure and the rather poor surgical outcomes for patients graded as N2 or higher, according to nodal involvement points to the fact that better pre-operative management is required in terms of tumor grading, induction chemotherapy and radiotherapy to decrease the risks associated with metastatic mediastinal nodal status.


KEY WORDS: Carina - Non-small cell lung carcinoma - Bronchogenic carcinoma - Node metastasis - Survival rates - Surgical outcome - Surgical management

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Lin H, Lu Y, Gu T, Wang J. Influence of nodal status on the surgical outcome for bronchongenic carcinoma involving the carina: a systematic review and meta-analysis. Minerva Chir 2017 May 30. DOI: 10.23736/S0026-4733.17.07382-5 

Corresponding author e-mail

wang_jun2016@sina.com