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REVIEW  RECTAL CANCER TREATMENT IN THE 21ST CENTURY 

Minerva Chirurgica 2018 December;73(6):601-18

DOI: 10.23736/S0026-4733.18.07743-X

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Non-operative management of rectal cancer: understanding tumor biology

Iris H. WEI , Julio GARCIA-AGUILAR

Colorectal Service, Department of Surgery, Memorial Sloan Kettering, New York, NY, USA



The management of locally-advanced rectal cancer involves a combination of chemotherapy, chemoradiation, and surgical resection to provide excellent local tumor control and overall survival. However, aspects of this multimodality approach are associated with significant morbidity and long-term sequelae. In addition, there is growing evidence that patients with a clinical complete response to chemotherapy and chemoradiation treatments may be safely offered initial non-operative management in a rigorous surveillance program. Weighed against the morbidity and significant sequelae of rectal resection, recognizing how to best optimize non-operative strategies without compromising oncologic outcomes is critical to our understanding and treatment of this disease.


KEY WORDS: Rectal neoplasms - Drug therapy - Chemoradiotherapy

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