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REVIEW  MANAGING EARLY ESOPHAGEAL CANCER ENDOSCOPICALLY 

Minerva Chirurgica 2018 August;73(4):417-27

DOI: 10.23736/S0026-4733.18.07795-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Role of confocal laser endomicroscopy in patients with early esophageal neoplasia

Marek KOLLAR 1 , Julius SPICAK 2, Eva HONSOVA 1, Jana KRAJCIOVA 2, Zuzana VACKOVA 2, Jan MARTINEK 2, 3, 4

1 Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2 Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 3 Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic; 4 Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic


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Probe-based confocal laser endomicroscopy (pCLE) enables real-time histopathological assessment during endoscopic procedures to evaluate epithelial and subepithelial structures with a 1000x magnification. It may be used in various localizations not only in the digestive tract, but its role in clinical practice is still a matter of discussion. The main advantages of pCLE compared to standard biopsies may be: 1) real-time diagnosis; 2) which may be done by the endoscopist; and 3) a larger evaluated area compared to standard biopsies. In theory, pCLE has the potential to eliminate the need for biopsy. However, pCLE cannot replace standard biopsies at this time, among others, standard forceps biopsies are presently more cost-effective. pCLE may be used to enhance the diagnostic arsenal and improve mucosal visualization and evaluation in patients with Barrett’s esophagus (BE), with visible esophageal lesions and in patients undergoing surveillance endoscopy after endoscopic treatment of BE related neoplasia. pCLE requires sufficient training and use of validated classifications systems. At present, the majority of endoscopic centers do not use pCLE routinely and no guidelines recommend its routine use for patients with different esophageal diseases, although pCLE is (in selected indications) reimbursed in some countries. This article describes the principle and performance of pCLE and reviews its use in patients with BE and early esophageal neoplasia.


KEY WORDS: Microscopy, confocal - Esophageal neoplasms - Barrett esophagus

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