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Review Article   

Minerva Cardiology and Angiology 2022 Jun 29

DOI: 10.23736/S2724-5683.22.06120-8

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Risk of atrial fibrillation among patients with premature ventricular complexes: a systematic review and meta-analysis of cohort studies

Pongprueth RUJIRACHUN 1 , Phuuwadith WATTANACHAYAKUL 1, Prawut PHICHITNITIKORN 1, Nipith CHAROENNGAM 2, Arjbordin WINIJKUL 3

1 Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2 Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 3 Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand


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BACKGROUND: Atrial fibrillation (AF) is more likely found in patients with premature ventricular complexes (PVCs). Nonetheless, the outcomes of previous investigations remain inconclusive. To evaluate the link between PVCs and the risk of AF, we did a systematic review and meta-analysis.
METHODS: Potentially eligible studies were found by searching for published publications indexed in the MEDLINE and EMBASE databases from inception to April 13, 2021, looking for studies that assessed the risk of AF in patients with PVCs vs those who did not have PVCs. Dersimonian and Laird's random-effect, generic inverse variance technique was used to calculate the pooled risk ratio (RR) and 95 % confidence interval (CI).
RESULTS: The meta-analysis includes 6 cohort studies (1 prospective and 5 retrospective cohort studies) with a total of 9,662,088 individuals. We found that patients with PVCs have a significantly higher risk of AF than individuals without PVCs with the pooled RR of 1.90 (95% CI, 1.51-2.39, I2 = 83%).
CONCLUSIONS: PVCs are significantly related with a 1.90-fold higher incidence of AF, according to the present systematic review and meta-analysis. Nonetheless, further research is needed to determine how this connection should be treated in clinical practice if it is causal.


KEY WORDS: Premature ventricular complex; Atrial fibrillation; Risk factor; Meta-analysis

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