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Minerva Cardiology and Angiology 2021 Oct 29

DOI: 10.23736/S2724-5683.21.05752-5

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Prognostic implications of different clinical profiles in hypertrophic cardiomyopathy

Domitilla RUSSO 1, Matteo SCLAFANI 1, Giacomo TINI 1, Maria B. MUSUMECI 1, Luca ARCARI 2, Luca R. LIMITE 3, Pietro FRANCIA 1, Camillo AUTORE 1

1 Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2 Cardiology Unit, Madre Giuseppina Vannini Hospital, Rome, Italy; 3 Arrhythmia Unit and Electrophysiology Laboratories, Department of Cardiology and Cardiothoracic Surgery, San Raffaele Hospital, Milan, Italy


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Hypertrophic cardiomyopathy (HCM) is a myocardial genetic disease relatively common in the general population with heterogenous clinical presentation, natural history and prognosis. About 60% of HCM patients have a stable clinical course, while others may experience a variety of HCMrelated complications which follows relatively independent pathways, and that can be distinguished in different subgroups. These subgroups are represented by patients with left ventricular outflow tract obstruction; patients with end-stage disease and reduced or preserved systolic function; patients with apical hypertrophy; patients with apical aneurysm; patients with atrial fibrillation, patients at high risk of sudden death and patients with pre-clinical HCM. The purpose of this review is to describe each of these clinical profiles with its prognostic implications.


KEY WORDS: Hypertrophic cardiomyopathy; Prognosis; Left ventricular outflow tract obstruction; Atrial fibrillation; End-stage hypertrophic cardiomyopathy; Apical aneurysm

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