Home > Journals > Minerva Cardiology and Angiology > Past Issues > Articles online first > Minerva Cardiology and Angiology 2021 May 04

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

Minerva Cardiology and Angiology 2021 May 04

DOI: 10.23736/S2724-5683.21.05666-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Pooled prevalence of three major cardiovascular risk factors in patients undergoing left main bifurcation stenting: a systematic review and meta-analysis

Gianluca RIGATELLI 1 , Marco ZUIN 2, Dobrin VASSILEV 3, ALBERTO MAZZA 4, Claudio BILATO 5, Loris RONCON 6

1 Section of Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy; 2 Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 3 Department of Cardiology, Alexandrovska University School of Medicine, Sofia, Bulgaria; 4 Hypertension Management Centre of Excellence, Department of Internal Medicine, Rovigo General Hospital, Rovigo, Italy; 5 Division of Cardiology, West Vicenza General Hospitals, Arzignano, Vicenza, Italy; 6 Division of Cardiology, Rovigo General Hospital, Rovigo, Italy



BACKGROUND: Prevalence of the major risk factors in patients with Left Main (LM) bifurcation disease has not been yet clearly assessed, although it would important for building up bifurcation computational models. We perform a systematic review and metaanalysis on the three major cardiovascular risk factors in patients treated for LM bifurcation disease using either single or 2-stent strategy.
MEHTODS: In accordance with the PRISMA guidelines, Cochrane Library, Embase, PubMed and Google Scholar were queried to locate articles published between January 2015 to October 2020, comparing single- versus 2-stent strategy and reporting the prevalence of arterial hypertension (HT), hyperlipidaemia (HyperL) and diabetes mellitus (DM).
RESULTS: Out of a total of 230 articles, 7 articles were included into the final analysis. A total of 4559 patients were enrolled: 2666 (58.4%, mean age 60.4 years, 2318 males) and 1933 patients (42.3%, mean age 64.8 years, 1763 males) received a single- and 2-stent stenting strategies, respectively. A random effect model revealed a pooled prevalence of HT, HyperL and DM in 69.4%, 38.9% and in 31% of cases, respectively. Prevalence of HT was lower in patients treated with single versus 2-stent strategy (63 versus 66.7% of patients, p=0.01) while HyperL and DM were more represented in single versus 2-stent strategy: 41.6 versus 34.1% (p<0.001), and 32.5 versus 31.8% of patients (p=0.61), respectively.
CONCLUSIONS: In patients with LM bifurcation disease undergoing either single or 2- stent strategy, HT, HyperL and DM are frequent comorbidities. In severe LM disease requiring 2-stent technique, HT is the most prevalent risk factor.


KEY WORDS: Left main coronary artery; Risk factor; Coronary artery disease; Atherosclerosis

top of page