REVIEW   Free access

Minerva Cardiology and Angiology 2023 October;71(5):504-14

DOI: 10.23736/S2724-5683.23.06414-1

Copyright © 2023 EDIZIONI MINERVA MEDICA

language: English

#FullPhysiology: a systematic step-by-step guide to implement intracoronary physiology in daily practice

Roberto SCARSINI ¹ ✉, Gianluca CAMPO ², Luigi DI SERAFINO ³, Sofia ZANON ¹, Francesca RUBINO ¹, Giovanni MONIZZI ⁴, Simone BISCAGLIA ², Marco ANCONA ⁵, Alberto POLIMENI ⁶, Giampaolo NICCOLI ⁷, Massimo FINESCHI ⁸, Italo PORTO ⁹, Antonio M. LEONE ¹⁰

¹ Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; ² Cardiology Unit, Ferrara University Hospital, Cona, Ferrara, Italy; ³ Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; ⁴ Department of Cardiology, Galeazzi-Sant’Ambrogio Hospital, Milan, Italy; ⁵ Cardiovascular Imaging Unit, Department of Cardiothoracic Surgery, IRCCS San Raffaele Hospital, Milan, Italy; ⁶ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy; ⁷ Department of Medicine, University of Parma, Parma, Italy; ⁸ Department of Interventional Cardiology, Senese University Hospital, Le Scotte Polyclinic Hospital, Siena, Italy; ⁹ Cardiology Unit, Department of Cardiothoracic and Vascular Surgery (DICATOV), San Martino Polyclinic Hospital, Genoa, Italy; ¹⁰ Diagnostic and Interventional Unit, Ospedale Fatebenefratelli Gemelli Isola Tiberina, Rome, Italy

#FullPhysiology is a comprehensive and systematic approach to evaluate patients with suspected coronary disease using PressureWire technology (Abbott Vascular, Santa Clara, CA, USA). This advancement in technology enables the investigation of each component of the coronary circulation, including epicardial, microvascular, and vasomotor function, without significantly increasing procedural time or technical complexity. By identifying the predominant physiopathology responsible for myocardial ischemia, #FullPhysiology enhances precision medicine by providing accurate diagnosis and facilitating tailored interventional or medical treatments. This overview aims to provide insights into modern coronary physiology and describe a systematic approach to assess epicardial flow-limiting disease, longitudinal physiological vessel analysis, microvascular and vasomotor dysfunction, as well as post- percutaneous coronary intervention (PCI) physiological results.

KEY WORDS: Myocardial ischemia; Physiopathology; Technology