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REVIEW  MYOCARDIAL AND PERICARDIAL DISEASE 

Minerva Cardiology and Angiology 2022 April;70(2):189-206

DOI: 10.23736/S2724-5683.21.05752-5

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Prognostic implications of different clinical profiles in hypertrophic cardiomyopathy

Domitilla RUSSO 1, Matteo SCLAFANI 1, Giacomo TINI 1, M. Beatrice MUSUMECI 1, Luca ARCARI 2, Luca R. LIMITE 3, Pietro FRANCIA 1, Camillo AUTORE 1

1 Unit of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University, Rome, Italy; 2 Unit of Cardiology, Madre Giuseppina Vannini Hospital, Rome, Italy; 3 Unit of Arrhythmia and Electrophysiology Laboratories, Department of Cardiology and Cardiothoracic Surgery, San Raffaele Hospital, Milan, Italy



Hypertrophic cardiomyopathy (HCM) is a myocardial genetic disease relatively common in the general population with heterogenous clinical presentation, natural history and prognosis. About 60% of HCM patients have a stable clinical course, while others may experience a variety of HCM-related complications which follows relatively independent pathways, and that can be distinguished in different subgroups. These subgroups are represented by patients with left ventricular outflow tract obstruction; patients with end-stage disease and reduced or preserved systolic function; patients with apical hypertrophy; patients with apical aneurysm; patients with atrial fibrillation, patients at high risk of sudden death and patients with preclinical HCM. The purpose of this review was to describe each of these clinical profiles with its prognostic implications.


KEY WORDS: Cardiomyopathy, hypertrophic; Prognosis; Ventricular outflow obstruction; Atrial fibrillation

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