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ORIGINAL ARTICLE
Minerva Cardiology and Angiology 2021 April;69(2):154-60
DOI: 10.23736/S2724-5683.20.05085-9
Copyright © 2020 EDIZIONI MINERVA MEDICA
language: English
Effects of treprostinil on pulmonary arterial hypertension during surgery for congenital heart disease complicated with severe pulmonary arterial hypertension
Huiwen JIANG 1, Xiaodan YU 2, Lina ZHANG 3, Minxin WANG 1 ✉
1 Department of Ultrasonography, Weihai Central Hospital, Weihai, China; 2 Blood Purification Center, Weihai Central Hospital, Weihai, China; 3 Penglai People’s Hospital, Yantai, China
BACKGROUND: The aim of this study is to evaluate the effects of treprostinil injection on the control of pulmonary blood pressure in children with congenital heart disease (CHD) complicated by severe pulmonary arterial hypertension (PAH).
METHODS: Eighty children with CHD complicated by severe pulmonary arterial hypertension admitted to our hospital from January 2015 to June 2018 were selected and randomly divided into a control group (N.=40) and a treatment group (N.=40). Based on standard treatment, the treatment group was intravenously infused with 8-12 ng/kg·min treprostinil, while the control group received the same dose of normal saline. Hemodynamic parameters such as BP, AP, P and SpO
RESULTS: For the treatment group, the HR values at T2 and T3 were lower than that at T0 (P<0.05). For the control group, HR at T3 was lower than that at T0 (P<0.05). HR at T3 of the treatment group was lower than that of the control group (P<0.05). SpO
CONCLUSIONS: Treprostinil can improve cardiac function and reduce pulmonary circulation resistance in PAH children.
KEY WORDS: Heart diseases; Pulmonary arterial hypertension; Treprostinil; Echocardiography