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Minerva Cardioangiologica 2020 Apr 23

DOI: 10.23736/S0026-4725.20.05153-1


language: English

Correlation of heart rate and blood pressure variability as well as hs-CRP with the burden of stable coronary artery disease

Xiong PENG, Dingfeng PENG, Yongjun HU, Hongsheng GANG, Yijun YU, Shaoyong TANG

Department of Cardiology, Wuhan No. 4 Hospital, Wuhan, China


OBJECTIVE: The aim is to investigate the predictive value of heart rate variability (HRV), blood pressure variability (BPV), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with stable coronary artery disease (SCAD) to assess whether these variables predict the Gensini score.
METHODS: 588 patients with SCAD were enrolled. Normal coronary angiography (102 patients) and healthy physical examination patients (104 patients) as control group for HRV. Dynamic electrocardiogram, ambulatory blood pressure, and hs-CRP were measured in SCHD, and Gensini scores were calculated. The relationship between the level of Gensini scores and HRV, BPV and hs-CRP in SCAD was analyzed. Assess the predictive value of non-invasive markers for the degree of coronary artery disease in SCAD.
RESULTS: HRV was negatively correlated with coronary lesions Gensini scores, and BPV was positively correlated with them. The correlation coefficients of SDNN, PNN50, SDANN, RMSSD, and TRIA in HRV are -0.327, -0.489, -0.153 -0.206, -0.292, respectively (P<0.01); while 24hSBPV, 24hDBPV, dSBPV, dDBPV, nSBPV and nSBPdrinBPV are 0.286, 0.233, 0.141, 0.139, 0.218, 0.113, respectively (P<0.01); hs-CRP was positively correlated with the Gensini scores of coronary lesions (0.325, P<0.01); HRV decreased (PNN50<14.97, TRIA<160.86) and BPV increased (24hSBPV>20%, nSBPV>20%) combined with hs-CRP positive (hs-CR>3.0 mg/L) performance can effectively predict coronary lesions in SCAD.
CONCLUSIONS: HRV, BPV and hs-CRP are all significantly associated with coronary lesions. And these variables can predict the Gensini score in SCAD.

KEY WORDS: Heart rate variability; Blood pressure variability; High-sensitivity C-reactive protein; Stable coronary artery disease

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