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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2017 Nov 20

DOI: 10.23736/S0026-4725.17.04574-1


language: English

From biodegradable polymers to bioresorbable vascular scaffolds: available evidence in the current era of new-generation DES

Fabio MAGLIULO 1, Raffaele PICCOLO 2, Anna FRANZONE 2, Giovanni ESPOSITO 1, Gian B. DANZI 3

1 Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy; 2 Department of Cardiology, Bern University Hospital, Bern, Switzerland; 3 Division of Cardiology, Ospedale Santa Corona, Pietra Ligure, Savona, Italy


New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts, biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicate a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES. Recently, polymer- free DES provided promising results particularly as alternative to bare-metal stents. Ultimately, although remaining conceptually solid, bioresorbable vascular scaffolds represent an immature technology owing to increased risk of thrombosis. In this review, we summarized current evidence about contemporary coronary devices.

KEY WORDS: Percutaneous coronary intervention - Coronary stent - Drug-eluting stent - Polymer - Vascular scaffold

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Publication History

Article first published online: November 20, 2017
Manuscript accepted: November 16, 2017
Manuscript received: November 15, 2017

Cite this article as

Magliulo F, Piccolo R, Franzone A, Esposito G, Danzi GB. From biodegradable polymers to bioresorbable vascular scaffolds: available evidence in the current era of new-generation DES. Minerva Cardioangiol 2017 Nov 20. DOI: 10.23736/S0026-4725.17.04574-1

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