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MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2017 Nov 20

DOI: 10.23736/S0026-4725.17.04573-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Neoatherosclerosis: from basic principles to intravascular imaging

Philipp NICOL 1 , Erion XHEPA 1, Dmitry BOZHKO 2, Michael JONER 1

1 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; 2 Institute for Biological and Medical Imaging (IBMI), Technische Universität München, Munich, Germany


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Development of new atherosclerotic lesions within the neointima of stented vessels has been recognized as a novel disease manifestation of atherosclerosis (neoatherosclerosis), often manifesting as in-stent restenosis (ISR) or in-stent thrombosis (ST). The pathobiology of this entity is still not fully understood and definite diagnosis is challenging owing to limitations in resolution of contemporary intravascular imaging modalities and lack of consequent histopathology correlation studies. Yet, intravascular imaging has emerged as the gold standard for the diagnosis of in-stent pathologies, the most routinely used modalities being intravascular ultrasound (IVUS) and optical coherence tomography (OCT). In this review, we will give a concise summary about the basic understanding and histological findings of neoatherosclerosis. We will focus on the description of in-vivo findings using IVUS and OCT, discussing advantages and pitfalls. Furthermore, recent developments regarding innovative molecular imaging techniques for a more precise and advanced examination of neoatherosclerotic plaques will be discussed.


KEY WORDS: Neoatherosclerosis - Intravascular imaging - optical coherence tomography (OCT) - Molecular imaging - PTCA

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Publication History

Article first published online: November 20, 2017
Manuscript accepted: November 17, 2017
Manuscript received: November 13, 2017

Cite this article as

Nicol P, Xhepa E, Bozhko D, Joner M. Neoatherosclerosis: from basic principles to intravascular imaging. Minerva Cardioangiol 2017 Nov 20. DOI: 10.23736/S0026-4725.17.04573-X

Corresponding author e-mail

nicol@dhm.mhn.de