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REVIEW  MODELING OF CARDIAC ARRHYTHMIAS 

Minerva Cardioangiologica 2017 August;65(4):380-97

DOI: 10.23736/S0026-4725.17.04362-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Cardiac computational modeling of ventricular tachycardia and cardiac resynchronization therapy: a clinical perspective 

Zhong CHEN 1, 2, 3 , Steve NIEDERER 1, Nesan SHANMUGAM 3, Maxime SERMESANT 4, Christopher A. RINALDI 1, 2

1 Division of Imaging Science and Biomedical Engineering, King’s College London, London, UK; 2 Department of Cardiology, Guy’s and St Thomas’ NHS Trust, London, UK; 3 Department of Cardiology, St George’s NHS Trust, London, UK; 4 Inria, Asclepios Team, Sophia Antipolis, France


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Computational modeling has contributed to the understanding of the normal cardiac electrophysiology and the mechanisms underlying arrhythmogenesis and arrhythmia maintenance. Our improved understanding of cardiac physiology and access to faster computational power have allowed us to integrate many layers of biological systems, gain further insight into the mechanism of cardiac pathology and moved from small scale molecular and cellular models to integrated three-dimensional models representing the anatomy, electrophysiology and hemodynamic parameters on an organ scale. The ultimate goal of cardiac modeling is to create personalized patient-specific models that would allow clinicians to better understand the disease pathology, aid diagnosis and plan treatment strategy on a case-by-case basis. Pioneers in the field have demonstrated that such approach have already impacted on the diagnosis and therapeutic treatment for ventricular arrhythmia and heart failure. This review demonstrates the feasibility to integrate computational modeling with clinical investigations in a clinical environment and to guide therapeutic treatment of cardiac arrhythmia and heart failure in real time for individual patients.


KEY WORDS: Patient-specific modeling - Computer simulation - Cardiac arrhythmias - Cardiac resynchronization therapy

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