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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2015 June;63(3):231-8


language: English

Pharmacological treatment and prevention of chronic venous ulcers: a review

Cerbone A. M., Tufano A., Coppola A., Cimino E., Di Minno M. N., Di Minno G.

Regional Reference Center for Coagulation Disorders, Department Of Clinical Medicine and Surgery, “Federico II” University Hospital, Naples, Italy


Chronic venous insufficiency and chronic venous ulcers represent an important medical problem, because of the high incidence and prevalence in the general population, and need to be considered as a lifelong degenerative condition, with socioeconomic consequences. Ulceration is a severe complication of the post-thrombotic syndrome, often precipitated by minor trauma. The rate of post-thrombotic syndrome varies between 20% and 100% of patients with deep vein thrombosis, mostly occurring within two years of an initial thrombotic event. This syndrome is difficult to treat, causes significant disability and reduces the quality of life. To date, there are no effective therapies of chronic venous ulcers and no definite strategies for identifying patients at risk for the development of ulceration. The role of adequate compression with elastic stockings is well recognized. Several systemic drugs have been tested for a possible effect on chronic venous ulcer healing, but none has been widely accepted as standard therapy in this setting. It has been suggested that extended oral anticoagulation should be investigated as a possible preventative measure. Waiting for the results in this field, an adequate management of anticoagulation in terms of anticoagulant intensity and duration should be recommended for the prevention of recurrent deep vein thrombosis, post-thrombotic syndrome and chronic venous ulcers.

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Cite this article as

Cerbone AM, Tufano A, Coppola A, Cimino E, Di Minno MN, Di Minno G. Pharmacological treatment and prevention of chronic venous ulcers: a review. Minerva Cardioangiol 2015 June;63(3):231-8. 

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