Home > Journals > Minerva Cardioangiologica > Past Issues > Minerva Cardioangiologica 2011 June;59(3) > Minerva Cardioangiologica 2011 June;59(3):255-70

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

REVIEWS   

Minerva Cardioangiologica 2011 June;59(3):255-70

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Clinical applicability of coronary atherosclerotic lesion characterization

Kaluski E., Waller A., Patel A., Gerula C., Maher J., Haider B., Klapholz M.

Division of Cardiology, Department of Medicine, University Hospital and New Jersey Medical School, Newark, NJ, USA


PDF


Native coronary atherosclerosis (CAS) is a diffuse and progressive disease process that is occasionally associated with either clinical atherothrombosis and/or major adverse cardiac events (MACE) including: ST elevation myocardial infarction (STEMI), acute coronary syndromes without ST elevation (ACSWSTE), heart failure, cardiac arrest and sudden cardiac death. Both, the timing and coronary site responsible for the MACE are currently unpredictable. Cardiovascular investigators have engaged in the task of characterizing CAS lesions in order to enhance our knowledge of CAS pathophysiology. It was expected that the knowledge acquired will allow scientists and clinicians to develop effective strategies to detect and treat “vulnerable plaque” (VP) prior to the evolution of MACE. This review discusses the emerging data regarding the pathology and natural history of the VP and vulnerable patient and the progress made in characterizing atherosclerotic plaque instability and vulnerability. Future directions in the field of plaque characterization and their potential clinical and research applications are discussed.

top of page