Home > Journals > Minerva Biotecnologica > Past Issues > Minerva Biotecnologica 2018 March;30(1) > Minerva Biotecnologica 2018 March;30(1):29-35

CURRENT ISSUE
 

ARTICLE TOOLS

Publication history
Reprints
Cite this article as

MINERVA BIOTECNOLOGICA

A Journal on Biotechnology and Molecular Biology


Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,25


eTOC

 

REVIEW  FREEfree


Minerva Biotecnologica 2018 March;30(1):29-35

DOI: 10.23736/S1120-4826.17.02306-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Role of serum hepatitis B core-related antigen in chronic hepatitis B infection

Gian P. CAVIGLIA 1 , Daniele NOVIELLO 1, Rinaldo PELLICANO 2, Antonella OLIVERO 1

1 Department of Medical Sciences, University of Turin, Turin, Italy; 2 Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy


PDF  


Hepatitis B core-related antigen (HBcrAg) is a novel serum marker consisting of hepatitis B core antigen, hepatitis e antigen (HBeAg) and a 22 kDa precore protein without C-terminal arginine rich domain. All these core-related proteins can be simultaneously detected in serum and quantified by chemiluminescence enzyme immunoassay. Current available data indicate that HBcrAg serum levels vary according to the different phases of chronic hepatitis B (CHB) infection showing a strong correlation with both serum HBV DNA and intrahepatic HBV covalently closed circular DNA (cccDNA). In addition, HBcrAg levels seem able to identify CHB patients likely to respond to interferon-based therapy and those treated with nucleos(t)ide analogues that have higher possibility of successful treatment cessation. Finally, recent data pointed out an association between HBcrAg levels and hepatocellular carcinoma (HCC) development and recurrence. In this review we report and discuss novel findings and clinical applications of HBcrAg determination in patients with chronic hepatitis B virus infection.


KEY WORDS: Biomarkers - Hepatitis B virus - Carcinoma, hepatocellular

top of page

Publication History

Issue published online: December 6, 2017
Manuscript accepted: July 6, 2017
Manuscript received: July 5, 2017

Cite this article as

Caviglia GP, Noviello D, Pellicano R, Olivero A. Role of serum hepatitis B core-related antigen in chronic hepatitis B infection. Minerva Biotec 2018;30:29-35. DOI: 10.23736/S1120-4826.17.02306-0

Corresponding author e-mail

caviglia.giampi@libero.it