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Minerva Biotecnologica 2018 March;30(1):1-6

DOI: 10.23736/S1120-4826.17.02246-7


language: English

Anti-insulin resistance effects of diarylheptanoids and flavonoids from Myrica rubra leaves

Pinghong CHEN 1, 2, Ching-Hsu YANG 3, Jeng-Yuan YAO 4, Jinmei XIA 5, Weibing ZHENG 5, Xiuna WU 1, Jinming LI 1, Yaying WANG 6, Guey-Horng WANG 7, Jianzhong XU 5, Lianzhong LUO 1, Yung-Husan CHEN 1, 8

1 Department of Pharmacy, Xiamen Medical College, Xiamen, China; 2 Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China; 3 Fineboon Dairy Nutrition Institute, Shaanxi Dairy Co. Ltd., Shaanxi, China; 4 Department of Basic Medical Science, Center for Translational Medicine, Xiamen Medical College, Xiamen, China; 5 Third Institute of Oceanography, Key Laboratory of Marine Biogenetic Resources, State Oceanic Administration, Xiamen, China; 6 Key Laboratory for Dao-Di Herbs Biotechnology of Fujian Province, Xiamen Medical College, Xiamen, China; 7 Research Center of Natural Cosmeceuticals Enginerring (RCNCE), Xiamen Medical College, Xiamen, China; 8 Xiamen Key Laboratory of Marine Medicinal Natural Products and Cell Engineering, Xiamen Medical College, Xiamen, China


BACKGROUND: Some human metabolic enzymes, including AMPK, Acetyl-CoA carboxylase, E1 ubiquitin activating enzyme, glycogen synthase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are key indexes of metabolic disorders caused by type II diabetes. These enzymes are important for insulin regulation and stability maintenance of the human body.
METHODS: We analyzed the effects of (2R)-3’,4”-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl)heptan-3-one (compound 1), myricanol (compound 2), myricetin (compound 3) and myricitrin (compound 4) extracted from Myrica rubra leaves on type II diabetes.
RESULTS: We discovered that 2R)-3’,4”-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl)heptan-3-one (compound 1) was the best compound to relieve metabolic disorders caused by type II diabetes.
CONCLUSIONS: We concluded that the four compounds promoted glycogen synthesis and improved the overall effectiveness of carbohydrate metabolism.

KEY WORDS: Myrica - Motor activity - Diabetes mellitus, type 2 - Metabolic diseases

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