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MINERVA BIOTECNOLOGICA

A Journal on Biotechnology and Molecular Biology


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Minerva Biotecnologica 2017 September;29(3):156-65

DOI: 10.23736/S1120-4826.17.02221-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Application of nanoparticles drug delivery systems in the treatment of intracellular bacterial infections

Ali RAZEI 1, Abdol M. CHERAGHALII 2 , Mojtaba SAADATI 3, Mahdi FASIHI Ramandi 4, Yunes PANAHI 5

1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; 2 Faculty of Pharmacy, University of Baqiyatallah Medical Sciences, Tehran, Iran; 3 Biology Research Center, Faculty of Basic Science, Imam Hossein University, Tehran, Iran; 4 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; 5 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


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Despite significant progresses in the development and emergence of new antibiotics, it is still a major problem to treat intracellular bacterial pathogens in human infections. Concentration in specific doses of antibiotics is often dependent on the type of treatment and some drugs may be prescribed in large doses for more efficiency. This is important not only economically, but also may cause localized or side effects in individual patients. On the other hand the emergence of antimicrobial resistance caused that treatment of inner celullar bacteria has not been successfully completed. The use of nanoparticles for drug delivery systems caused to optimize the effectiveness of the treatment process and subsequently better in this kind of infections. polymeric nanoparticles are of particular importance due to biodegradability and biocompatibility. On the other hand, the nanoparticles particularly increase the phagocytic activity and operate as desired in drug delivery systems. Due to great efforts in recent years in the field, there is no doubt that the nanoparticles improve the treatment of intracellular bacterial agents, optimize the chronic infections and minimize their side effects. In this review, applicaions of drug delivery systems are used, leading to effective performance on target bacteria.


KEY WORDS: Brucellosis - Drug delivery systems - Dendrimers - Nanoparticles - Liposom - Listeriosis - Quantum dots - Tuberculosis

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Publication History

Issue published online: July 19, 2017
Manuscript accepted: March 10, 2017
Manuscript received: February 21, 2017

Cite this article as

Razei A, Cheraghalii AM, Saadati M, Fasihi Ramandi M, Panahi Y. Application of nanoparticles drug delivery systems in the treatment of intracellular bacterial infections. Minerva Biotec 2017;29:156-65. DOI: 10.23736/S1120-4826.17.02221-2

Corresponding author e-mail

majidcheraghali@gmail.com