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REVIEWS  7th INTERNATIONAL CONFERENCE ON TRANSGLUTAMINASES AND PROTEIN CROSSLINKING REACTIONS
Ferrara (Italy), September 14-17, 2002
 

Minerva Biotecnologica 2002 June;14(2):159-64

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English

Differentiation therapy of cancer. Transglutaminase as differentiative tool

Lenini A., Beninati S.

Department of Biology, University of Rome “Tor Vergata”, Rome, Italy


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Differentiation therapy is a new approach to the treatment of advanced or aggressive malignancies and may be significantly efficacious in the treatment of many types of cancer. Several research projects are focused on different approaches to the study of cancer cell differentiation, all of which serve to complement one another. Our experimental address in this field is the identification of new molecules able to induce cancer cell differentiation by enhancing transglutaminase (TGase) activity. Recently, retinoic acid and theophylline appeared particularly promising as inducers of differentiation in cultured melanoma cell lines. This overview will explore the potential mechanism(s) involved in the action of these molecules, evaluating the possibility of their therapeutical applications.

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