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DNA MICROARRAY TECHNOLOGIES MEETING
Minerva Biotecnologica 2001 December;13(4):249-54
Copyright © 2002 EDIZIONI MINERVA MEDICA
language: English
Yeast in the post-genomic era. Use of DNA microarrays to study stress response, response to drugs and alkylating agents in Saccharomyces cerevisiae
De Filippo C. 1, Cavalieri D. 2
1 Department of Pharmacology, University of Florence, Florence, Italy; 2 Center for Genomic Research, Harvard University, Cambridge MA
The advent of powerful new DNA arrays technologies has catapulted yeast Saccharomyces cerevisiae in a pioneering position in the post-genomic era. The promises of this new technology are to allow exploiting the complete genome sequence and understanding of the dynamic cascades of events that drive the biology of the cell. This is to say that we will pass from the study of a specific gene to the observation of the complex pathways of gene expression. The information will allow unraveling the signaling networks, integrating the function of different genes, providing insights in the big picture that explains how genotype connects to phenotype. In order to achieve this task, the experimental design is fundamental. A sub-optimal experimental design causes addition of confusion to a complex process. The work that is carried on the yeasts is of fundamental importance, not only for the understanding of the biology of one of the most important model organisms, but as it allows developing new approaches optimizing the experimental designs, teaching how to use and improve DNA micro-arrays, how to ask questions and understand the answers.