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ORIGINAL ARTICLE   

Minerva Biotechnology and Biomolecular Research 2021 December;33(4):219-25

DOI: 10.23736/S2724-542X.20.02642-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Fabrication of medicinal transdermal patch impregnated with silver nanoparticles synthesized from biomedical photographic wastes

Thiruvenkadasamy R. POORANI , Selvam ISWARYA, Mythili PRIYA, Sri D. SIVAKUMAR, S. KANNAN

Department of Biotechnology, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, India



BACKGROUND: In last few decades the usage of silver becomes supplementary advantageous in many fields. Especially in health care sector this silver plays a major role in curing lot of defects. With the improvement of nanotechnology in recent days, the silver nanoparticles (AgNPs) have its own competence due to its improved characteristic as fabricated AgNPs. Silver based nanomaterials have a better scope, challenging and promising applications in aiding the controlled drug release in enormous biomedical applications.
METHODS: Biomedical photographic waste usually contains metal ions mostly silver, sodium, potassium and iron. Since silver is photosensitivity material and its valuable increasing price, people tend to recover the silver from biomedical photographic waste to reuse it in various industries. Since silver is an important metal and major cast component of the film used in X-ray, MRI and CT scans. It is recovered from used or waste chemicals during film developing. In this study the silver is recovered from biomedical photographic waste fixer solution by precipitation method. Using this silver, stable silver nanoparticle is synthesized using various physical and chemical methods. Since AgNPs are having antimicrobial property, it is incorporated in transdermal patch to improve its antimicrobial efficiency for various treatments.
RESULTS: The synthesized silver nanoparticle based transdermal patch was characterized for its efficiency by various analytical techniques, evaluation of transdermal patch and invitro drug release studies.
CONCLUSIONS: This paved the way to produce ecofriendly, low cost transdermal patch through green synthesis of AgNPs from water hyacinth using biomedical wastes to improve the effectiveness and efficiency of bandages with patient compliance.


KEY WORDS: Nanoparticles; Transdermal patch; Eichhornias

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