REVIEW   

Minerva Biotecnologica 2020 June;32(2):64-78

DOI: 10.23736/S1120-4826.19.02595-3

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Micro bioreactor scale-up and industrialization: a critical review of the methods, their prerequisites, and perquisites

Mehrdad EBRAHIMZADEH KOUCHESFAHANI, Valiollah BABAEIPOUR ✉

Section of Bioscience and Biotechnology, Department of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Tehran, Iran

Scaling up of micro bioreactors is not always an economical or practicable process. Though, some extra cases of successful trends of micro bioreactors industrialization have been reported and shown many developments until the present time. It has not been feasible yet to get a generalized formula for scale up; One that is gotten from the specifications of a certain system, so that it would account for any specific system’s specifications under arbitrary operating parameters values and various circumstances. Being aware of the selectivity, outstanding developments, the uprising techniques and new systems introduced in the present decade, the need for a complete research of the evolutionary approaches and their prerequisites, representation of their usefulnesses, their drawbacks and limitations seems essential. These urgent needs will be addressed as a review here; So that there will be a prologue in hand for later novel engineering ideas, and the limitations in the field of reaching to industrial micro bioreactors are removed.

KEY WORDS: Bioreactors; Industrial development; Review