TECHNICAL NOTES   

Minerva Biotecnologica 2008 September;20(3):133-5

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

A simultaneous dual-isotope acquisition and imaging fusion protocol in nuclear medicine: 111In-Octreotide SPECT and 99mTc-HMDP bone SPECT

Zanotti-Fregonara P. ¹, Keller I. ², Devaux J. Y. ², Massaro A. ³, Rubello D. ³, Hindié E. ⁴

¹ DSV/IBM/SHFJ/LIME Commissariat à l’Energie Atomique, Orsay, France 2 Service de Médecine Nucléaire Hôpital St Antoine, Paris, France 3 Department of Nuclear Medicine PET Center, S. Maria della Misericordia Hospital, Rovigo, Italy 4 Service de Médecine Nucléaire, Hôpital St Louis, Paris, France

In the present preliminary study, we developed a protocol for the acquisition and fusion of dual-isotope tomographic (SPECT) images (111In-Octreotide SPECT and 99mTc-HMDP SPECT). This procedure was performed in ten consecutive patients, and the first results were encouraging: it proved to be a simple and accurate method to improve the anatomic localization of 111In-Octreotide SPECT positive foci for the staging and follow-up of tumours expressing somatostatin receptors (Octreotide is an analog of somatostatin), particularly in discriminating bone metastases from soft tissue metastases located near to bone itself.