Home > Journals > Minerva Anestesiologica > Past Issues > Articles online first > Minerva Anestesiologica 2022 Apr 13



Publishing options
To subscribe
Submit an article
Recommend to your librarian


Publication history
Cite this article as


Original Paper   

Minerva Anestesiologica 2022 Apr 13

DOI: 10.23736/S0375-9393.22.16346-7


language: English

Analgesic benefit of metamizole and ibuprofen vs. either medication alone: a randomized clinical trial

Tobias SCHNEIDER 1 , Eckhard MAUERMANN 1, Bernd ILGENSTEIN 2, Claude JAQUIERY 3, Wilhelm RUPPEN 1

1 Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland; 2 Ambulatory Clinic for Oral and Maxillofacial surgery Ilgenstein, Solothurn, Switzerland; 3 Clinic for Oral and Maxillofacial surgery, Basel, Switzerland


BACKGROUND: Postoperative pain relief remains a key problem after surgery. Multimodal pain therapy has proven beneficial in alleviating pain to a certain extent. However, when combining non-opioids, the focus has been on NSAIDs and paracetamol, but effects of combined use are only moderate. Metamizole could be a potent adjunct, due to its preclusion in several countries, data on its combined use are sparse, despite its common use in many countries. The aim of this study was to examine whether the combination of metamizole and ibuprofen is superior in relieving postoperative pain to either drug alone.
METHODS: For this randomized, placebo-controlled, cross-over study, 35 patients undergoing bilateral lower third molar extraction were randomized. Each patient received three applications of 1000mg metamizole + 400mg ibuprofen for surgery on one side and either 1000mg metamizole + placebo or 400mg ibuprofen + placebo on the other side. Pain ratings, rescue-medication (tramadol), and sleep were assessed for 18 hours.
RESULTS: The combined treatment of metamizole and ibuprofen showed lower mean pain scores over 12 hours than ibuprofen (2.4±1.3 vs 3.8±1.6; P=0.005)). Further, combined treatment showed lower mean pain scores over 6 hours than ibuprofen (2.0±1.2 vs. 3.1±1.6; P=0.022) or metamizole alone (2.0±1.2 vs. 3.3±1.7; P=0.015). Consumption of rescue medication was lowest in the combination-group (25% vs. 46%-metamizole; 50%-ibuprofen). The trial was stopped prematurely as the COVID-pandemic halted elective surgeries.
CONCLUSIONS: Combined use enables superior pain control compared to ibuprofen after molar extraction and tends to be superior to metamizole alone. The premature study-termination may overestimate this effect.

KEY WORDS: Acute postoperative pain; Multimodal analgesia; NSAID; Metamizole; Molar extraction; Ambulatory pain management

top of page