Home > Journals > Minerva Anestesiologica > Past Issues > Articles online first > Minerva Anestesiologica 2021 Feb 16

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

Minerva Anestesiologica 2021 Feb 16

DOI: 10.23736/S0375-9393.20.14855-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study

Hüseyin A. FINDIKLI 1 , Murat ERDOĞAN 2

1 Department of Internal Medicine, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş, Turkey; 2 Department of Intensive Care Unit Internal Diseases, Adana City Training And Research Hospital, Adana, Turkey


PDF


BACKGROUND: The sex hormone estrogen has an immune-supporting role in both trauma and sepsis-related to its immune-modulator role. The aim of the current study was to examine the prognostic role of (Serum G Protein-Coupled Estrogen Receptor-1) GPER-1 in sepsis and sepsis-related mortality.
METHODS: Prospective evaluation was made of the data on a total 160 patients followed up in the Intensive Care Unit because of sepsis. Patients were separated into two groups as survivor and non-survivor group. The Sequential Organ Failure Assessment (SOFA) score, APACHE II score and Charlson Comorbidity Index (CCI) were calculated for each patient. Serum GPER-1 levels were evaluated for each patient.
RESULTS: Compared with non-survivors, the surviving patients were determined with significantly higher levels of PLT, CRP, GPER-1, SOFA, and APACHE II scores. The GPER-1 levels showed a significant positive correlation with CRP levels, SOFA, and APACHE II scores. ROC curve analysis demonstrated 85.7% sensitivity and 72.1% specificity of GPER-1 to predict 28-day mortality. GPER-1 and APACHE II scores were determined to be an independent prognostic factor for predicting mortality.
CONCLUSIONS: Serum GPER-1 can be used as a new prognostic factor for survival in patients diagnosed with sepsis.


KEY WORDS: Estrogen; Estrogen receptors; GPER-1; Sepsis; mortality

top of page