Home > Journals > Minerva Anestesiologica > Past Issues > Articles online first > Minerva Anestesiologica 2020 May 22

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

 

Minerva Anestesiologica 2020 May 22

DOI: 10.23736/S0375-9393.20.14012-4

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?

Wael F. HASSAN 1, Mona H. TAWFIK 2 , Tamer M. NABIL 3, Rehab M. ABD ELKAREEM 4

1 Department of Anaesthesia, Beni-Suef University, Beni-Suef, Egypt; 2 Department of Neurology, Beni-Suef University, Beni-Suef, Egypt; 3 General Surgery, Department of General Surgery, Beni-Suef University, Beni-Suef, Egypt; 4 Clinical and Chemical Pathology, Department of Clinical and Chemical Pathology, Beni-Suef University, Beni-Suef, Egypt


PDF


BACKGROUND: Although there is much concern about the pathogenesis of postoperative cognitive dysfunction (POCD); no effective prevention strategies are currently described. The aim of this work was to study whether intraoperative magnesium sulphate could have a protective effect against developing POCD and to study its impact on serum level of S100B; a marker of neuronal degeneration.
METHODS: This is a prospective randomized controlled trial carried out on 80 participants undergoing elective laparoscopic cholecystectomy, 40 participants received conventional general anaesthesia (conventional anaesthesia group) and 40 participants received conventional general anaesthesia with extra administration of intraoperative magnesium sulphate (Mg sulphate group). Cognitive assessment for both groups was done preoperatively and 1 week postoperatively using Paired Associate Learning test (PALT) and Benton Visual Retention test (BVRT). Quantitative determination of serum S100B was done for both groups preoperatively and 1 week postoperatively by using an enzyme- linked immunoabsorbent assay technique.
RESULTS: Postoperative PALT and BVRT were significantly lower than preoperative PALT and BVRT in the conventional anaesthesia group (P-value = 0.043, P-value = 0.015 respectively), but not in the Mg sulphate group (P-value = 0.134, P-value = 0.151 respectively). Postoperative S100B was significantly higher than preoperative S100B in the conventional anaesthesia group (P-value = 0.006), but not in the Mg sulphate group (P-value = 0.293).
CONCLUSIONS: Administration of intravenous infusion of magnesium sulphate during conventional general anaesthesia can protect against POCD and attenuate the post operative elevation of serum S100B.


KEY WORDS: Mg sulphate; PALT; BVRT; S100B

top of page