Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2020 February;86(2) > Minerva Anestesiologica 2020 February;86(2):205-16



Publishing options
To subscribe
Submit an article
Recommend to your librarian


Publication history
Cite this article as


REVIEW   Free accessfree

Minerva Anestesiologica 2020 February;86(2):205-16

DOI: 10.23736/S0375-9393.19.13842-4


language: English

Continuous nerve block versus single-shot nerve block for total knee arthroplasty: a meta-analysis from randomized controlled trials

Tao MA 1, Qingshan LIU 1, Liang ZHOU 2, Kai YUE 1, Zhongjun DING 1, Bing CHEN 3

1 Department of Orthopedics, The First People’s Hospital of Longquanyi District, Chendu, China; 2 Frontier Defense Medical Service Training Group, Army Medical University, Changji, Xinjiang Uyghur Autonomous Region, China; 3 Department of Anesthesia, The General Hospital of Western Theater Command, Chendu, China

INTRODUCTION: This meta-analysis aims to determine whether continuous nerve block (CNB) provides better pain relief and functional recovery than single-shot nerve block (SSNB) after total knee arthroplasty (TKA).
EVIDENCE ACQUISITION: Embase, PubMed, and the Cochrane Library databases were comprehensively searched. Randomized controlled trials (RCTs) with a modified Jadad Score ≥4 comparing CNB with SSNB in patients after TKA were enrolled in our meta-analysis. The primary outcomes were visual analogue scale (VAS) pain score and morphine consumption. The secondary outcomes were distance able to ambulate, complications and length of hospital stay. Review Manager 5.3 for Windows was used to analyze the extracted data.
EVIDENCE SYNTHESIS: Two RCTs that compared continuous adductor canal block (ACB) with single-shot ACB, and four RCTs that compared continuous femoral nerve block (FNB) with single-shot FNB were included in our meta-analysis. There were no significant differences in VAS scores at rest for 12 hours (P=0.44), 24 hours (P=0.15) and 48 hours (P=0.16) postoperatively, VAS scores on activity for 24 hours (P=0.15) and 48 hours (P=0.23), total opioid consumption at 12 hours (P=0.20), 24 hours (P=0.25) and 48 hours (P=0.41), distance walked at 24 hours (P=0.58) and 48 hours (P=0.93), nausea and vomiting at 24 hours (P=0.18) and 48 hours (P=0.62), and length of hospital stay (P=0.71) between the CNB and SSNB groups.
CONCLUSIONS: CNB and SSNB have similar effects on pain relief, complications and functional recovery in patients receiving TKA. The optimal analgesic regimen for patients after TKA needs further identification.

KEY WORDS: Knee replacement arthroplasty; Meta-analysis; Nerve block; Continuous analgesia

top of page