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MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2018 April;84(4):473-80

DOI: 10.23736/S0375-9393.17.12051-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Agreement between ccNexfin CO-trek cardiac output and intermittent cold-bolus pulmonary thermodilution in a prospective multicenter study

Nicolaas H. SPERNA WEILAND 1 , Jim W. de WEVER 2, Yoni van DUIVENVOORDE 2, Christa BOER 2, Ludmil MITREV 3, Muhammad MUNTAZAR 3, Kinjal PATEL 3, Markus W. HOLLMANN 1, Benedikt PRECKEL 1

1 Department of Anesthesiology, Academic Medical Center (AMC) Amsterdam, University of Amsterdam, Amsterdam, The Netherlands; 2 Department of Anesthesiology, Free University Medical Center, Amsterdam, The Netherlands; 3 Department of Anesthesiology, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA


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BACKGROUND: The ccNexfin System uses the CO-trek algorithm to analyze a non-invasively obtained arterial pressure waveform and calculate cardiac output (NEXCO). It remains matter of debate whether NEXCO can replace invasive, pulmonary artery catheter-derived, cold-bolus pulmonary thermodilution cardiac output measurement (PACCO). This study aimed at testing NEXCO-PACCO agreement in a large sample size, multicenter study. We hypothesized that agreement between NEXCO and PACCO would be demonstrated by a mean accuracy (bias) <0.6 L/min with a percentage error <30%.
METHODS: Patients undergoing cardiac surgery in three academic hospitals clinically requiring pulmonary artery catheterization were included. Exclusion criteria were aortic, pulmonary and tricuspid (valve) abnormalities, non-sinus rhythm and insufficient perfusion of the digits such as in Raynaud’s disease. After induction of anesthesia, cardiac output was measured with four cold bolus thermodilution measurements and four averaged 30-second ccNexfin measurements randomized through the respiratory cycle to obtain one measurement pair. Mean accuracy and precision of ccNexfin were expressed as bias (mean of all NEXCO-PACCO differences) and limits of agreement (LOA) (1.96·SD of bias). Percentage error was calculated as [LOA / (NEXCO-PACCO average)].
RESULTS: Fifty-five patients were enrolled in the study, 51 completed the protocol. Median PACCO was 3.7 (IQR: 3.2 to 4.6) L/min and median NEXCO was 3.8 (IQR: 3.1 to 4.7) L/min. NEXCO-PACCO bias was 0.1 (LOA: -1.4 to +1.6) L/min with a 37% percentage error.
CONCLUSIONS: In this study, cardiac output measurement with ccNexfin failed to meet the predefined criteria for agreement with cold-bolus pulmonary artery thermodilution.


KEY WORDS: Cardiac output - Swan-Ganz catheterization - Pulse wave analysis - Thermodilution - Validation studies as topic

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Publication History

Issue published online: April 10, 2018
Article first published online: December 13, 2017
Manuscript accepted: November 30, 2017
Manuscript revised: November 21, 2017
Manuscript received: March 8, 2017

Cite this article as

Sperna Weiland NH, de Wever JW, van Duivenvoorde Y, Boer C, Mitrev L, Muntazar M, et al. Agreement between ccNexfin CO-trek cardiac output and intermittent cold-bolus pulmonary thermodilution in a prospective multicenter study. Minerva Anestesiol 2018;84:473-80. DOI: 10.23736/S0375-9393.17.12051-1

Corresponding author e-mail

n.h.spernaweiland@amc.uva.nl