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Minerva Anestesiologica 2018 February;84(2):236-45

DOI: 10.23736/S0375-9393.17.12016-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Machine perfusion in liver transplantation: an essential treatment or just an expensive toy?

Andrea A. SCHLEGEL 1, 2, 3, 4, Marit KALISVAART 1, Paolo MUIESAN 1, 3

1 The Liver Unit, Queen Elizabeth University Hospital, Birmingham, UK; 2 NIHR Liver Biomedical Research Unit, University Hospitals Birmingham, Birmingham, UK; 3 Department of Liver Surgery, Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK; 4 Department of Surgery & Transplantation, University Hospital Zurich, Zurich, Switzerland


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This review focuses on recent developments in preservation techniques in liver transplantation. First, we discuss mechanisms of organ injury when using high-risk organs, including donation after circulatory death and steatotic grafts and we summarize pathways of ischemia reperfusion injury together with their link to the immune response. Second, we report on improvement strategies of marginal liver grafts by different machine perfusion concepts and summarize perfusion approaches with recent clinical implementation.


KEY WORDS: Perfusion - Liver transplantation - Biomarkers

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