Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2018 February;84(2) > Minerva Anestesiologica 2018 February;84(2):159-67



Publication history
Cite this article as


A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,623




Minerva Anestesiologica 2018 February;84(2):159-67

DOI: 10.23736/S0375-9393.17.12042-0


language: English

Physiological effects of the open lung approach during laparoscopic cholecystectomy: focus on driving pressure

Davide D’ANTINI 1 , Michela RAUSEO 1, Salvatore GRASSO 2, Lucia MIRABELLA 1, Luigi CAMPOROTA 3, 4, Antonella COTOIA 5, Savino SPADARO 5, Alberto FERSINI 6, Rocco PETTA 1, Rosaria MENGA 1, Alberto SCIUSCO 7, Michele DAMBROSIO 1, Gilda CINNELLA 1

1 Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy; 2 Department of Anesthesia and Intensive Care, University of Bari, Bari, Italy; 3 Asthma, Allergy and Lung Biology Division, King’s College London, London, UK; 4 Department of Adult Critical Care, Guy’s and St Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK; 5 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy; 6 Department of General Surgery, University of Foggia, Foggia, Italy; 7 Department of Intensive Care and Anesthesia, North Bristol NHS Trust, Bristol, UK


BACKGROUND: During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum and atelectasis formation. We applied an open lung approach (OLA) consisting in lung recruitment followed by a decremental positive-end expiratory pressure (PEEP) trial to identify the level of PEEP corresponding to the highest compliance of the respiratory system (best PEEP). Our hypothesis was that this approach would improve both lung mechanics and oxygenation without hemodynamic impairment.
METHODS: We studied twenty patients undergoing laparoscopic cholecystectomy. We continuously recorded respiratory mechanics parameters throughout a decremental PEEP trial in order to identify the best PEEP level. Furthermore, lung and chest wall mechanics, respiratory and transpulmonary driving pressures (ΔP), gas exchange and hemodynamics were recorded at three time-points: 1) after pneumoperitoneum induction (TpreOLA); 2) after the application of the OLA (TpostOLA); 3) at the end of surgery, after abdominal deflation (Tend).
RESULTS: The “best PEEP” level was 8.1±1.3 cmH2O (range 6 to 10 cmH2O), corresponding to the highest compliance of the respiratory system (CRS). This “best PEEP” level corresponded with lowest ΔPL. OLA increased the compliance of the lung and of the chest wall, and decreased ΔPRS and ΔPL. PaO2/FiO2 increased from 299±125 mmHg to 406±101 mmHg (P=0.04). Changes in respiratory mechanics, driving pressures and oxygenation were maintained until Tend. Hemodynamic parameters remained stable throughout the study period.
CONCLUSIONS: In patients undergoing laparoscopic cholecystectomy, the OLA was suitable for bedside PEEP setting, improved lung mechanics and gas exchange without significant adverse hemodynamic effects.

KEY WORDS: Respiratory mechanics - Pneumoperitoneum - Laparoscopic cholecystectomy

top of page

Publication History

Issue published online: February 28, 2018
Article first published online: July 5, 2017
Manuscript accepted: June 24, 2017
Manuscript revised: June 8, 2017
Manuscript received: March 6, 2017

Cite this article as

D’Antini D, Rauseo M, Grasso S, Mirabella L, Camporota L, Cotoia A, et al. Physiological effects of the open lung approach during laparoscopic cholecystectomy: focus on driving pressure. Minerva Anestesiol 2018;84:159-67. DOI: 10.23736/S0375-9393.17.12042-0

Corresponding author e-mail