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MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2017 December;83(12):1309-16

DOI: 10.23736/S0375-9393.17.12034-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Risk of spontaneous fungal peritonitis in hospitalized cirrhotic patients with ascites: a systematic review of observational studies and meta-analysis

Marco FIORE 1 , Paolo CHIODINI 2, Vincenzo POTA 1, Pasquale SANSONE 1, Maria B. PASSAVANTI 1, Sebastiano LEONE 3, Caterina AURILIO 1, Maria C. PACE 1

1 Department of Anesthesiological, Surgical and Emergency Sciences, “Luigi Vanvitelli” University of Campania, Naples, Italy; 2 Unit of Medical Statistics, “Luigi Vanvitelli” University of Campania, Naples, Italy; 3 Division of Infectious Diseases, “San Giuseppe Moscati” Hospital, Avellino, Italy


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INTRODUCTION: Spontaneous fungal peritonitis (SFP) is an infection of ascitic fluid occurring in cirrhotic patients. SFP prevalence varies from 0% to 41% of patients with spontaneous peritonitis (SP) and a positive ascitic fluid culture. Cirrhotic patients with SFP who fail to show improvement with empirical antibiotic therapy, before the identification of the fungal pathogen, have high mortality (89.5-100%). Although the weight of the disease is so dramatic, more recent guidelines on infections in cirrhosis do not consider SFP management. The aim of this meta-analysis was to investigate the association between hospitalization (at least 48-72 hours after admission) and risk of SFP.
EVIDENCE ACQUISITION: A literature search was performed on PubMed, Scopus and Web of Science to identify relevant studies published up to March 2, 2017. Only observational studies that specify the etiology of SP were included. Data were pooled using risk difference as a summary measure and corresponding 95% confidence interval (CI).
EVIDENCE SYNTHESIS: Thirteen cohort studies were included in the meta-analysis (12 retrospective and one prospective). A pooled risk difference, using a random effects model, of nosocomial versus non-nosocomial SFP was 2.9% (95% CI, 0.4% to 5.3%, P=0.024) with a no significant heterogeneity among studies (P=0.090, I²=37%).
CONCLUSIONS: This meta-analysis suggests that hospitalization is related to a significant increase of SFP risk.


KEY WORDS: Peritonitis - Mycoses - Cross infection - Meta-analysis as topic - Liver cirrhosis

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Publication History

Issue published online: December 20, 2017
Article first published online: July 20, 2017
Manuscript accepted: July 19, 2017
Manuscript revised: June 8, 2017
Manuscript received: March 2, 2017

Cite this article as

Fiore M, Chiodini P, Pota V, Sansone P, Passavanti MB, Leone S, et al. Risk of spontaneous fungal peritonitis in hospitalized cirrhotic patients with ascites: a systematic review of observational studies and meta-analysis. Minerva Anestesiol 2017;83:1309-16. DOI: 10.23736/S0375-9393.17.12034-1

Corresponding author e-mail

marco.fiore@hotmail.it