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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2017 April;83(4):361-8

DOI: 10.23736/S0375-9393.16.11506-8


language: English

Hypobaric versus isobaric spinal levobupivacaine for total hip arthroplasty

Alessandro VERGARI 1, Luciano FRASSANITO 1, Roberta NESTORINI 1, Cosimo T., CAPUTO 1, Angelo CHIERICHINI 1, Enrico DI STASIO 2, Marco ROSSI 1

1 Institute of Anesthesia and Intensive Care, Center of Emergency and Internal Medicine, A. Gemelli University Policlinic Foundation, Sacro Cuore Catholic University, Rome, Italy; 2 Institute of Clinical Chemistry, Center of Diagnostic Imaging and Laboratory Medicine, A. Gemelli University Policlinic Foundation, Sacro Cuore Catholic University, Rome, Italy


BACKGROUND: Spinal anesthesia (SA) in the lateral decubitus position is often used to perform total hip arthroplasty (THA). Hypobaric local anesthetic ensures enhanced and prolonged sensory and motor block in the involved side. The aim of this study was to compare the intraoperative anesthetic efficacy of hypobaric with isobaric levobupivacaine solutions for THA.
METHODS: Forty patients scheduled to elective THA were allocated into two groups: isobaric levobupivacaine group (IL group) and hypobaric levobupivacaine group (HL group). All the patients were placed with the operative side uppermost on the surgical table and spinal anesthesia was performed with 4 mL (12.5 mg) of selected solution. The evolution of sensory and block on nondependent (operative) and dependent sides were checked.
RESULTS: Regarding the nondependent side the onset times for maximal sensory block level in the in HL group was 17.8±1.1 minutes vs. 24.2±4.1 minutes in IL group. In HL group the onset time for motor block was 9.2±3.5 minutes vs. 15.6±5.4 minutes in IL group. The sensory regression time to L2 was significantly prolonged in HL group (192±30.3 minutes vs. 111±13.4 min). After surgery in HL group the residual motor block degree was 2.4±0.9 vs. 0.2±0.4 in IL group.
CONCLUSIONS: In patients undergoing THA under spinal anesthesia 12.5 mg of hypobaric levobupivacaine, compared with the same dose of isobaric levobupivacaine, allow shorter onset time for sensory block and delayed regression of sensory and motor block in the nondependent side.

KEY WORDS: Arthroplasty - Replacement, hip - Anesthesia, spinal - Levobupivacaine

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Publication History

Issue published online: April 12, 2017
Article first published online: November 23, 2016
Manuscript accepted: November 17, 2016
Manuscript revised: November 4, 2016
Manuscript received: June 23, 2016

Cite this article as

Vergari A, Frassanito L, Nestorini R, Caputo CT, Chierichini A, Di Stasio E, et al. Hypobaric versus isobaric spinal levobupivacaine for total hip arthroplasty. Minerva Anestesiol 2017;83:361-8. DOI: 10.23736/S0375-9393.16.11506-8

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