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Minerva Anestesiologica 2017 March;83(3):315-20

DOI: 10.23736/S0375-9393.16.11698-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Opioid-less perioperative care

Juan P. CATA 1, 2, 3, Dario BUGADA 3, 4, 5, Jose, de ANDRÉS 3, 6

1 Department of Anesthesiology and Perioperative Medicine, M.D. Anderson Cancer Center, Houston, TX, USA; 2 Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA; 3 SIMPAR Group, Parma, Italy; 4 Department of Surgical Sciences, University of Parma, Parma, Italy; 5 Department of Anesthesia, ICU and Pain Therapy, Parma University Hospital, Parma, Italy; 6 Department of Anesthesia, Critical Care and Multidisciplinary Pain Management, Valencia University General Hospital, Valencia, Spain


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Opioids are the most frequently administered analgesics in the perioperative period. The analgesic potency of opioids is without question. While the “opioid-free” or “opioid-less perioperative care” concept is not a reality in most surgical centers of the United States and other developed countries, there is a significant number of healthcare problems (i.e., adverse events, opioid-induced hyperalgesia and opioid diversion) related to the indiscriminate use of opioids that warrants the implementation of multimodal analgesia strategies. Although it has been suggested an association between the use of opioids and cancer progression, there is a need of well-designed studies to confirm that association.


KEY WORDS: Opioid analgesics - Perioperative care - Drug-related side effects and adverse reactions

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