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MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2017 March;83(3):302-14

DOI: 10.23736/S0375-9393.16.11268-4

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Biological markers of injury-induced immunosuppression

Christelle ROUGET 1, 2, 3, Thibaut GIRARDOT 1, 2, 3, Julien TEXTORIS 1, 2, 3, Guillaume MONNERET 1, 2, 4, Thomas RIMMELÉ 1, 2, 3, Fabienne VENET 1, 2, 4

1 Joint Research Unit, Hospices Civils de Lyon, BioMérieux, Edouard Herriot Hospital, Lyon, France; 2 EAM Pathophysiology of Injury-Induced Immunosuppression, UCBL1-HCL-BioMérieux, Lyon, France; 3 Anesthesiology and Intensive Care Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France; 4 Immunology Laboratory, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France


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Severe injuries, such as severe sepsis, burn, trauma and major surgery, lead to an overlapping development of pro- and anti-inflammatory responses. It is now well established that these injuries are associated with the secondary development of immune suppression, which results in significant morbidity and mortality. Recent data suggest that immunostimulatory drugs might prevent these complications. However, intensive care patients are heterogeneous, making patient stratification essential for a targeted treatment. In the present review, we discuss potential biomarkers of injury-induced immunoparalysis, mainly focusing on these that have been associated with poor outcome in various clinical settings. We namely present clinical data on monocyte human leukocyte antigen DR, lymphopenia, PD-1/PD-L1 and transcriptomic approach.


KEY WORDS: Wounds and injuries - Sepsis - Immunosuppression - Biomarkers - Monitoring, immunologic

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Publication History

Issue published online: March 20, 2017
Article first published online: June 17, 2016
Manuscript accepted: June 15, 2016
Manuscript revised: May 4, 2016
Manuscript received: February 12, 2016

Cite this article as

Rouget C, Girardot T, Textoris J, Monneret G, Rimmelé T, Venet F. Biological markers of injury-induced immunosuppression. Minerva Anestesiol 2017;83:302-14. DOI: 10.23736/S0375-9393.16.11268-4

Corresponding author e-mail

fabienne.venet@chu-lyon.fr