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Minerva Anestesiologica 2014 August;80(8):942-53

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Increasing the number of lungs available for transplantation

Del Sorbo L. 1, 2, Parotto M. 1, Slutsky A. S. 1, 3

1 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; 2 Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Torino, Italia; 3 Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, ON, Canada


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Lung transplantation has become a standard treatment for patients with a broad spectrum of end stage lung diseases. Despite this success, many patients die on the waiting list while waiting for appropriate lungs to become available. This review describes the current strategies aimed at addressing this shortage of lungs, as well as summarizing potential future directions in the field. They include efforts to: 1) increase the number of organ donors by legislative action, and education of the public; 2) optimize the management of deceased, potential organ donors; 3) implement optimal criteria to determine organs suitable for transplantation; 4) use ex vivo reconditioning of lungs; and 5) develop xenotransplantation.

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