Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2011 December;77(12) > Minerva Anestesiologica 2011 December;77(12):1216-23

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints

 

EXPERT OPINIONS   Freefree

Minerva Anestesiologica 2011 December;77(12):1216-23

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Use of synthetic colloids in sepsis: a critical review on efficacy, safety and patient benefits

Trof R. J. 1, Groeneveld A. B. J. 2

1 Department of Intensive Care, Medisch Spectrum Twente, Enschede, The Netherlands; 2 Department of Intensive Care, VU Medical Centre, Amsterdam, The Netherlands


PDF


In this narrative review, the studies and analyses are discussed that pertain to benefits and detriments of synthetic colloids versus natural colloids or crystalloids used for fluid resuscitation in sepsis and septic shock. The relative amount of fluid infusions used to reach clinical or hemodynamic end-points are reviewed, as well as potential toxicity of starch solutions on the kidney. Hence, it cannot be excluded that adverse effects partly offset beneficial hemodynamic effects that are similar to that of natural colloids, so that in most analyses a mortality benefit of synthetic colloid fluid resuscitation in sepsis and septic shock cannot be demonstrated.

top of page