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Minerva Anestesiologica 2011 March;77(3):371-4

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Therapeutic hypothermia for space-occupying Herpes simplex virus encephalitis

Wagner I. 1, Staykov D. 1, Volbers B. 1, Kloska S. 2, Dörfler A. 2, Schwab S. 1, Bardutzky J. 1

1 Department of Neurology, University of Erlangen-Nuremberg, Germany; 2 Department of Neuroradiology, University of Erlangen-Nuremberg, Germany


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Development of space-occupying edema in patients with severe Herpes simplex virus encephalitis is a major factor for high morbidity and mortality. Conventional intracranial pressure-lowering modalities are limited and more aggressive treatment options for such patients have rarely been described. This article reports on a HIV-positive patient with Herpes simplex type 2 encephalitis and elevated intracranial pressure refractory to medical therapy. Induced moderate hypothermia of 33 °C resulted in fast and sustained control of intracranial pressure. After three months, the patient had a fairly good functional outcome with a Glasgow Outcome Scale score of 4.

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