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Minerva Anestesiologica 2008 September;74(9):481-8

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Statistical methods for evidence-based medicine: the diagnostic test. Part II

Antonelli P. 1, Chiumello D. 2, Cesana B. M. 1

1 Medical Statistics and Biometry Unit, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy; 2 Department of Anesthesia and Intensive Care “Maggiore, Policlinico, Mangiagalli, Regina Elena” Hospital IRCCS Foundation University of Milan, Milan, Italy


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Part II of this work addresses the use of likelihood ratios for the calculation of a positive predictive value (PPV) and a negative predictive value (NPV) for patient diagnosis. These two values are the most useful indices in the application of a diagnostic test in order to make a diagnosis for a patient. Furthermore, the relevance of sample size is also addressed by providing background theory and pertinent tables. These basic topics for assessing the validity of a diagnostic test and for performing appropriate and valid case vs control studies are explained in a simple way for a clinical audience with a working example.

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