Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2001 April;67(4) > Minerva Anestesiologica 2001 April;67(4):290-1

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

SEPSI  SMART 2001 Freefree

Minerva Anestesiologica 2001 April;67(4):290-1

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Cytopathic hypoxia in sepsis: a true problem?

Fink M. P.

From the University of Pittsburgh Medical School Watson Professor of Surgery Chief, Division of Critical Care Medicine Anesthesiology and Critical Care Medicine Pittsburgh, USA


PDF


It is increas­ing­ly appar­ent ­that ­organ dys­fun-cti­on in sep­sis is ­caused, at ­least in ­part, by an ­acquired intrin­sic derange­ment in cel­lu­lar oxi­da­tive aden­o­sine tri­phos­phate (ATP) pro­duc­tion. We ­have ­termed ­this phe­nom­e­non “cyto­path­ic hypox­ia”. ­Although sev­er­al dif­fer­ent but mutu­al­ly com­pat­ible mech­a­nisms ­might ­account for the devel­op­ment of cyto­path­ic hypox­ia in sep­sis, ­recent ­data ­from our labor­a­to­ry ­point to acti­va­tion of the nucle­ar ­enzyme, ­poly-ADP-ribo­syl poly­me­rase (­PARP), as ­being the ­most impor­tant.

top of page