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Minerva Anestesiologica 2001 April;67(4):193-7

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Genetic susceptibility to respiratory diseases

Villar J.

Research Institute, Hospital N. S. de Candelaria Tenerife, Canary Islands, Spain Associate Scientist, Department of Medicine Mount Sinai Hospital, Toronto, Canada Clinical Professor, Critical Care Medicine, Mercer University, Macon, Georgia, USA


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As a result of the progress in molecular biology and genetics over the last 20 years, now it seems clear that the pathogenesis of most diseases is influenced by the genotype, the environment and the nature of the process which leads to the injury. Current evidence also suggests that genetic factors are associated with susceptibility to pulmonary diseases. The author reviews some of these complex interactions suggesting that even the inflammatory response during lung injury can be influenced by genetic polymorphisms.

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