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Minerva Anestesiologica 2000 October;66(10):749-56

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Ketorolac for paediatric postoperative pain. A review

Di Massa A., Scardigli M., Bruni L., Valentino L.

From the Università degli Studi - Siena Dipartimento di Scienze Odontostomatologiche Cattedra di Terapia del Dolore *Istituto di Anestesiologia e Rianimazione

Ketorolac, a non­ster­oid­al ­anti-inflam­ma­to­ry ­drug (­NSAID) large­ly ­used in ­adults, ­deserves par­tic­u­lar atten­tion for post­op­er­a­tive ­pain ther­a­py in chil­dren, ­even if it is not offi­cial­ly ­approved for paed­i­at­ric use. We ­have exam­ined a lot of stud­ies ­about the use of ketor­o­lac for paed­i­at­ric post­op­er­a­tive ­pain, point­ing out phar­mac­o­log­i­cal and phar­ma­cok­i­net­ic prop­er­ties and ­side ­effects. There are sig­nif­i­cant dif­fer­enc­es in phar­ma­cok­i­net­ic param­e­ters, dos­es, ­routes of admin­is­tra­tion, ­length of treat­ment, ­side ­effects, ­usage pre­cau­tions and phar­mac­o­log­i­cal inter­ac­tions ­between chil­dren and ­adults. Amongst the ­many ­drugs avail­able, ketor­o­lac ­seems to be par­tic­u­lar­ly effi­cient for post­op­er­a­tive ­pain ther­a­py in chil­dren too.